Elucidating the molecular mechanisms of translocation of Cell Penetrating Peptides


Cell-penetrating peptides (CPPs), such as TAT, polyarginine or penetratin, are short, positively charged amino acid sequences, that allow direct translocation of bioactive cargoes across cellular membranes. This property has been used in fundamental and applied biology since the end of the 1980’s to deliver a variety of compounds into cells. Recent studies have investigated the CPP potential to treat human diseases, such as wound healing, heart attack, and inflammation. However, our incomplete understanding of the way CPPs enter cells hamper further development and improvement of CPP-derived compounds.

This project is carried out in collaboration with the Laboratory of Cell Penetrating Peptide Biology of University of Lausanne (Prof. C. Widmann).